Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4

摘要

The crystal structure of human factor VIIa/soluble tissue factor in complex with a highly selective peptide-mimetic factor VIIa inhibitor has been solved at 2.6 Å resolution. This structure suggests that Asp60 and Lys192 are key residues for achieving high selectivity against thrombin inhibition.